Regulation (isocitrate dehydrogenase)
Isocitrate dehydrogenase is non-equilibrium and flux-generating within the tricarboxylic acid cycle. It exists in 2 subtypes which are affected by different sets of regulators:
- NAD-linked dehydrogenase:
- stimulated by:
- increasing concentration of NAD
- increasing concentration of ADP
- increasing concentration of calcium
- inhibited by increasing concentration of NADH
- stimulated by:
NADPH-linked dehydrogenase:
þþ stimulated by increasing concentration of NADP
- inhibited by increasing concentration of NADPH
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