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Rapidly progressive glomerulonephritis

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This type of glomerulonephritis is also known as crescenteric glomerulonephritis after the 'crescents' seen on light microscopy. These crescents are collections of epithelial cells and macrophages within Bowman's space.

The presence of crescents indicates that glomerular damage is rapid and progressive (from onset to endstage renal failure within weeks to months).

Immunofluorescence detects deposits of IgG or complement factor C3 in the glomerular basement membrane. There are three distributions of immunofluorescence in crescentic glomerulonephritis:

  • absent immunofluorescence
  • granular immunofluorescence
  • linear immunofluorescence

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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