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Cardiac glycosides

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Cardiac glycosides block Na K ATPase, increasing sodium calcium exchange thus increasing intracellular Ca, with the following effects:

  • positive inotropism
  • disturbance of rhythm by:
    • blocking the AV conduction
    • increasing ectopic pacemaker activity
  • negative chronotropy, mediated via increased vagal activity

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