Non-steroidal anti-inflammatory drugs
Non-steroidal anti-inflammatory drugs (NSAIDS) act to reduce inflammation and pain by interupting the synthesis of prostaglandins.
NSAIDS inhibit the enzyme cyclo-oxygenase (COX).
As single dose for acute pain there is probably no advantage of NSAIDs over paracetamol; however with chronic inflammatory conditions regular NSAID therapy offers prolonged pain relief with a useful anti-inflammatory action.
Despite their efficacy, NSAIDs are limited by their gastrointestinal side-effects, particularly gastric ulceration.
NICE suggest that a clinician should
- co-prescribe a PPI for people over 45
Reference:
Related pages
- Types of NSAID
- Method of action
- Specific indications
- Side effects
- Prevention of peptic ulceration due to NSAIDs
- Choosing an NSAID or cox-2 inhibitor
- NSAIDS and diuretics
- Aspirin and nonspecific non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular disease (CVD) risk
- Antidepressant treatment and non-steroidal anti-inflammatory drugs (NSAIDs)
- Use of NSAIDs in abnormal uterine bleeding
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