Type 1 diabetes has been clearly shown to be a polygenic disorder, with nearly 40 loci known to affect disease susceptibility (1)
Risk of developing the disease is higher in relatives of diabetic patients. In siblings, the risk is greater than in offsprings, and there is a high concordance rate among identical twins (2)
The HLA region of chromosome 6 is most closely linked to susceptibility to IDDM:
Other genes such as the insulin gene on chromosome 11 have been implicated.
Reference:
Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page