Genetic loci

A recent genome-wide search for human type-1 susceptibility genes revealed five loci:

• IDDM1:
  • chromosome 6p21
  • the gene is in the major histocompatibility complex
  • accounts for 42% of the familial clustering of the disease in the study
    
    
• IDDM2:
  • chromosome 11p15
  • this is near the insulin gene
  • accounts for 10% of the familial clustering of the disease in the study
    
    
• IDDM4:
  • chromosome 11q
    
    
• IDDM5:
  • chromosome 6q
    
    
• a fifth locus may exist on chromosome 18