Risk categories for selected prognostic factors
With the identification and validation of new prognostic factors, patients can be categorised into high, intermediate and low risk for disease progression (1).
- high risk
- del (17p)/TP53 gene mutation
- del (11q)
- IgHV unmutated
- CD38 positive
- ZAP-70 positive
- lymphocyte doubling time < 6 months
- b2-microglobulin > 3.5 mg/L
- intermediate
- trisomy 12
- trisomy 12
- low
- del(13q)
- normal cytogenetics
- mutated IgHV (1)
Reference:
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