Classification of congenital hypothyroidism

Congenital hypothyroidism can be divided into:

• permanent congenital hypothyroidism - there is continuous deficiency of thyroid hormone and requires treatment throughout life, can be further divided into
  
  
  • primary hypothyroidism - results from thyroid gland development (dysgenesis) or a disorder of thyroid hormone biosynthesis (dyshormonogenesis)
  • secondary or central hypothyroidism - deficiency of thyroid stimulating hormone (TSH)
    
    
• peripheral hypothyroidism - due to defects of thyroid hormone transport, metabolism, or action
  
  
• syndromic hypothyroidism - congenital hypothyroidism is associated with abnormalities of other organ systems
  
  
• transient congenital hypothyroidism - temporary deficiency which recovers during the first few months or years of life (1)

Reference:

• 1. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010;5:17