Pharmacokinetics
- digoxin half-life = 40 hours; elimination = renal; plasma concentration < 3 ng/ml
- digitoxin half-life = 5 days; elimination = metabolic; plasma concentration < 30 ng/ml
The plasma concentrations are those below which the drug should be kept to minimise the risk of toxicity.
Reference:
- 1) Oxford Textbook of Clinical Pharmacology and Drug Therapy. Third Edition. Editors D.G. Grahame-Smith and J.K. Aronson. Oxford: Oxford University Press, 2002
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