This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Granulocyte colony stimulating factors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Granulocyte colony stimulating factors are naturally occurring cytokines which increase the rate of maturation of granulocytes within the bone marrow. They were developed for limited clinical use on the assumption that reducing the severity and duration of the neutropaenia - for example after the administration of chemotherapy - will decrease the risks of infection.

In practice, G-CSF does improve the neutrophil count and may have a role in the management of neutropenia induced by cytotoxic chemotherapy. GM-CSF increases monocytes, eosinophils and neutrophils. There is some evidence that GM-CSF may increase the antibody-dependent cytolysis of some tumour cells.

Other areas of potential use without proven benefit as yet:

  • aplastic anaemia
  • myelodysplasia
  • AIDS

Side effects of GM-CSF, less so with G-CSF, include:

  • lethargy
  • bone pain
  • myalgia
  • anorexia
  • erythema at injection site
  • fever
  • increased serum alkaline phosphatase and lactic dehydrogenase

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page