This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Granulopoiesis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Granulopoiesis is the formation of granulocytes within the bone marrow. It is controlled by a number of substances including granulocyte colony stimulating factors.

The cell differentiation is sequentially:

  • stem cell progenitor
  • promyelocyte:
    • relatively large nucleus
    • basophilic cytoplasm
  • myelocytes, divided into cell lines distinguishable by granule staining within cytoplasm:
    • basophilic myelocyte
    • neutrophilic myelocyte
    • eosinophilic myelocyte
  • metamyelocyte cell lines:
    • granules are becoming more concentrated within cell
    • cell nucleus becomes more lobulated
    • gives rise to:
      • mature basophil
      • mature eosinophil
      • band cell

The band cell is an immature neutrophil that develops in the bone marrow by further lobulation of its nucleus.

The mature neutrophils, or band cells if a left shift has occurred, along with mature basophils and eosinophils, pass through the sinus endothelium in bone marrow through to blood.


Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.