Intrinsic haemolytic anaemia
Hereditary:
- disorders of red cell membrane - for example:
- hereditary spherocytosis
- hereditary elliptocytosis
- disorders of haemoglobin synthesis - for example:
- sickle cell disease
- thalassaemia
- deficiencies of red cell enzymes - most commonly:
- glucose-6-phosphatase dehydrogenase
- pyruvate kinase
Acquired:
- membrane defect - paroxysmal nocturnal haemoglobinuria
Reference
- Kim Y, Park J, Kim M. Diagnostic approaches for inherited hemolytic anemia in the genetic era. Blood Res. 2017 Jun;52(2):84-94.
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