Patients with thalassaemia major present within the first year of life with the following features:
At birth babies with thalassaemia major are asymptomatic until the age of 4-6 at which time fetal heamoglobin (Hb F) is replaced by Adult heamoglobin (Hb A) (1)
If untreated then eventually the progressive anemia and metabolic stress will lead to cardiac failure and infection and eventually death by the age of five (1).
Reference:
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