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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • CMV retinitis in patients with AIDS in whom ganciclovir is inappropriate
  • immunocompromised patients with acyclovir - resistant HSV infections - especially, bone marrow transplant recipients


  • inhibits DNA polymerase of HSV and CMV


  • monitor serum creatinine and calcium
  • ensure adequate hydration
  • renal impairment
  • hypocalcaemia


  • pregnancy and breast feeding


  • nausea and vomiting
  • hypocalcaemia
  • decreased haemoglobin concentration
  • hypoglycaemia, convulsions and thrombophlebitis if given undiluted by peripheral vein
  • headache
  • fatigue
  • rash
  • impairment of renal function including acute renal failure

Routes of administration:

  • i.v. infusion

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