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Side effects of antiviral nucleoside analogues

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Antiviral nucleoside analogues inhibit cellular nucleotide polymerases as well as their primary targets which are the viral polymerases or reverse transcriptases. Mitochondrial DNA polymerase (pol-gamma) is particularly sensitive to inhibitions by ANA's.

The common presentations of ANA toxicity include:

  • myopathy, including cardiomyopathy
  • haematological disturbance
  • neuropathy

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