This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

HIV infection of macrophages versus T-cells

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Different isolates of HIV-1 have varying tropisms for CD4 positive cells:

  • during the early stages of infection HIV is predominatly macrophage-tropic (M-tropic)
  • during later stages of infection HIV isolates are T-cell tropic (T-tropic)

CD8 positive cells can inhibit the replication of HIV by two means:

  • cell-mediated cytolysis of infected cells
  • secretion of soluble factors

Three soluble factors have been found which specifically inhibit M-tropic HIV replication:

  • RANTES
  • MIP-1 alpha
  • MIP-1 beta

These three inhibitory factors bind to a chemokine receptor called CCR-5. Subsequent work has shown that CCR-5 on macrophages is the co-receptor, along with CD4, for M-tropic HIV infection.

One soluble factor has been found which specifically inhibits T-tropic HIV replication:

  • SDF-1

SDF-1 binds to a chemokine receptor called CXCR-4. CXCR-4 (also called fusin) on T-cells is the co-receptor, along with CD4, for T-tropic HIV infection.


Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.