Inhibition of T cell - antigen presenting cell interaction

There are experimental approaches to inhibiting the presentation of the pathogenic antigen to T helper cells:

• copolymer and mixtures of peptides which mimic myelin protein sequences may compete with the pathogenic antigen for access to MHC II sites:
  • glatitramer acetate may work in this way
    
    
• patients may be vaccinated against specific sequences in the T cell receptor which are found on self-reactive T cells
  
  
• the following factors may downregulate MHC II expression:
  • TGF-beta
  • IL-10
  • interferon beta