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Aetiology

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Examples of extravascular haemolysis include:

  • sickle cell disease:
    • during a crisis, hypoxia results in gelling of the HbS
    • the red cell become less deformable
    • phagocytosis within mononuclear cells in the spleen results in extravascular haemolysis
  • hereditary spherocytosis:
    • the abnormal cytoskeleton reduces the deformability of the red cells

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