Progressive muscular atrophy
This is a rare form of motor neurone disease (MND).
Progressive muscular atrophy results from a lesion of anterior horn cells. The presentation is with asymmetrical limb wasting and weakness progressing to a condition where lower motor neurone signs predominate.
PMA accounts for 2.5-11% of cases of MND. It is predominantly seen in males, with a male to female ratio ranging from 3 to 7.5 to 1. The median age of onset is of 68 years, which is older than that of ALS (amyotrophic lateral sclerosis) patients (1).
Reference
- Liewluck T, Saperstein DS. Progressive Muscular Atrophy. Neurol Clin. 2015 Nov;33(4):761-73.
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