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Regulation (isocitrate dehydrogenase)

Authoring team

Isocitrate dehydrogenase is non-equilibrium and flux-generating within the tricarboxylic acid cycle. It exists in 2 subtypes which are affected by different sets of regulators:

  • NAD-linked dehydrogenase:
    • stimulated by:
      • increasing concentration of NAD
      • increasing concentration of ADP
      • increasing concentration of calcium
    • inhibited by increasing concentration of NADH

NADPH-linked dehydrogenase:

þþ stimulated by increasing concentration of NADP

  • inhibited by increasing concentration of NADPH

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