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Bone sarcoma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Osteosarcoma accounts for about 40% of primary malignancies of bone, the highest incidence occurring in the second decade of life.

The development of an osteosarcoma in later life usually is a secondary development to, e.g. Paget's disease of the bone, radioactive elements in the bone, or a pre-existing osteoclastoma.

Males are affected more commonly than females, with a ratio of approximately 2:1.

Osteosarcomas are more common in certain sites :

  • lower end of femur - about 40%
  • upper end of humerus - about 10%
  • pelvic bones - about 10%

i.e. the important sites are the metaphyses.

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