This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Ewing's sarcoma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Ewing's sarcoma is a malignant small cell tumour of bone, more common in males and having its highest incidence in the age group 5 to 20 years. It usually occurs in the diaphysis of long bones.

Ewing's sarcomas account for about 2% of paediatric malignancies:

  • Ewing's sarcoma arises predominantly in children and young adults, with an incidence of 1 case per 1.5 million population, a frequency among persons of European ancestry that is almost 10 times as high as the frequency among those of African ancestry, a slight predilection for males (ratio of cases among males to cases among females, 1.6:1.0), and a peak incidence at 15 years of age
  • is the second most common bone cancer in children, and can occur in any part of the body but most commonly involves the pelvis and proximal long bones
    • most often occurs in the femur, humerus, tibia, pelvis and ribs. Metastasis occurs early, usually to the lungs and other bones.
  • in approximately 20% of patients, tumors are extraosseous and can arise in numerous organs; extraosseous Ewing's sarcoma occurs much more frequently in adults than in children

Ewing's sarcoma may mimic an infective process and present with localised swelling, redness, heat and fever. There may be a raised WBC and ESR. Biopsy is needed for diagnosis.

  • most important prognostic factor is the presence of metastasis at the time of diagnosis
  • patients with local disease that responds to multimodal therapy currently have a 5-year survival rate of more than 70%
  • less than 30% of patients presenting with metastases survive for 5 years

Reference:

  • Riggi N et al. Ewing’s Sarcoma. N Engl J Med 2021;384:154-64.DOI: 10.1056/NEJMra2028910

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.