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Invasive lobular carcinoma of breast

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Invasive lobular carcinoma of the breast accounts for about 10% of all breast carcinoma. It may occur in combination with ductal carcinoma.

Clinically, it tends to present with distortion of the breast contour. Bilateral disease is more common than with ductal carcinoma in situ.

Macroscopically, it displays:

  • consistency rubbery
  • occasionally, hard or scirrhous

Histologically, there is:

  • strands of tumour cells:
    • small
    • uniform
    • little pleomorphism
  • loosely dispersed in fibrous stroma
  • occasionally encircle normal acini: characteristic "bull's eye" pattern

There are several histological types:

  • classical
  • solid
  • alveolar
  • mixed
  • pleomorphic

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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