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Raltitrexed

Authoring team

Raltitrexed is an inhibitor of thymidylate synthase. It is licensed for use as monotherapy when fluorouracil-based palliative therapy for colorectal cancer is inappropriate or not tolerated (1).

Adverse effects:

  • raltitrexed is more likely than infused fluorouracil/folinic acid to cause severe nausea, diarrhoea, anorexia, lethargy, neutropenia and thrombocytopenia (1)
  • if raltitrexed is used then monitoring of renal function is essential (dose should be adjusted if creatinine clearance is below 65 mL/minute) (1)

Reference:

  1. Drug and Therapeutics Bulletin (2002), 40(7), 50-2.

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