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Non-steroidal anti-inflammatory drugs (NSAID) and diuretics

Authoring team

  • if possible, NSAIDs should not be administered with diuretics - this is because NSAIDS antagonise the antihypertensive and diuretic affects of the diuretic
  • also co-administration of NSAIDs and diuretics also increases the risk of nephrotoxicity

Reference

  1. Morales D et al. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015 Aug;88(2):396-403.

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