This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in


Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The defect RTA-I prevents the distal tubule from generating, or maintaining, the normal 900:1 hydrogen ion concentration gradient across its wall.

Systemic acidosis results in calcium resorption from bone and hypercalciuria.

Nephrocalcinosis and urinary stones are common, being the result of:

  • hypercalciuria
  • alkaline urine: calcium phosphate tends to precipitate out in alkaline urine
  • low urinary citrate excretion: citrate chelates calcium and reduces precipitation

Hypokalaemia results from:

  • a lack of intraluminal hydrogen ions, resulting in exchange of potassium for luminal sodium
  • increased sodium losses, resulting in secondary hyperaldosteronism and hence hypokalaemia

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page