This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

AFP in testicular cancer

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • AFP - raised levels are seen most frequently in germ cell tumours and hepatocellular carcinoma, but also in gastric, colon, biliary, pancreatic and lung cancers (~20% of patients)
  • elevated serum AFP levels indicate the presence of yolk sac elements, i.e. mixed germ cell tumours (especially embryonal carcinoma and yolk sac tumours), and occur in all stages of disease [sensitivity 50-80% in metastatic disease, 70-72% in undifferentiated malignant teratoma, 60-64% in intermediate malignant teratoma, and 64% of patients with yolk sac or combination tumours]. AFP concentrations >1000 (850 kU/L) m g/L are found in 53% of undifferentiated malignant teratomas, 16% of intermediate malignant teratomas, and 26% of combination tumours (1)
  • elevated serum AFP levels may provide stronger evidence than histology in distinguishing pure seminomas and tumours with trophoblastic elements


  1. Doherty AP, Bower M, Christmas TJ: The role of tumour markers in the diagnosis and treatment of testicular germ cell cancers. Br J Urol 79: 247-252, 1997.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page