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Dopamine agonist induced adverse effects

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

These include:

  • nausea
  • dizziness and postural hypotension
  • these adverse effects are dose-related - they can be limited by increasing the dose slowly and often reduce with continued therapy

Other side effects include:

  • neuropsychiatric toxicity e.g. vivid dreams, hallucinations, hypersexuality, delusions - often associated with paranoia, confusion
  • neuropsychiatric toxicity is commoner in older patients, those with underly cognitive deficits, those who have suffered neuropsychiatric adverse reactions from other antiparkinsonian medication; also these side effects are more common when other antiparkinsonian medication and dopamine agonists are used concomitantly
  • neuropsychiatric side effects are not strongly dose - related; however reduction of the dose of dopamine agonist sometimes improves neuropsychiatric toxicity but may result in aggravation of parkinsonism. A reduction in the dose of other antiparkinsonian drugs, especially anticholinergics, may help
  • uncommon idiosyncratic side-effects include inflammatory pleuro-pulmonary disease

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