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Postmenopausal osteoporosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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During and after the menopause there is a marked tendency for women to lose bone material. Bone density decreases with time and may cross a hypothetical fracture threshold.

Thereafter the patient is at an increased risk of bone fractures including:

  • crush fractures of the vertebral body
  • neck of femur
  • distal forearm

The time taken to reach the threshold depends on:

  • the peak bone mass } factors affecting these are
  • the rate of bone loss } discussed under risk factors

In the decade immediately preceding the menopause, there is an annual rate of bone loss of about 0.3% of bone mass per year. This increases to 1-3% in the first 4 years after the menopause but then slows to about 0.6% subsequently.

Postmenopausal osteoporosis is thought to result from osteoclastic activity unbalanced by that of osteoblasts as the latter have been shown to be directly stimulated by oestrogens.

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