Last reviewed 01/2018

Osteosarcoma accounts for about 40% of primary malignancies of bone, the highest incidence occurring in the second decade of life.

The development of an osteosarcoma in later life usually is a secondary development to, e.g. Paget's disease of the bone, radioactive elements in the bone, or a pre-existing osteoclastoma.

Males are affected more commonly than females, with a ratio of approximately 2:1.

Osteosarcomas are more common in certain sites :

  • lower end of femur - about 40%
  • upper end of humerus - about 10%
  • pelvic bones - about 10%

i.e. the important sites are metaphyses.