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Atopic asthma is the result of airways inflammation caused by exposure to an environmental allergen.
Patients with asthma have an exuberant Th2-mediated IgE humoural immune response.
IgE binds to bronchial mast cells via the FcERI (high affinity receptor) resulting in degranulation and the release of pro-inflammatory mediators.
There are two phases of inflammation:
The results of inflammation are: