Regulation of the tricarboxylic acid cycle occurs at several key sites:
The key themes are:
Occasionally, the absence of co-factors, such as FAD for succinate dehydrogenase, will make other equilibrium reactions within the TCA cycle into rate-limiting steps.
The activity of pyruvate dehydrogenase indirectly regulates flux through the TCA cycle by determining the rate of provision of acetyl-CoA to citrate synthase.
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