Regulatory genes of HIV-1
The HIV genome codes for several regulatory proteins, including:
- tat:
- accelerates the rate of viral transcription
- accelerates the rate of viral transcription
- rev:
- rev regulates the balance of transcription of the regulatory proteins (tat & rev) versus the structural proteins (gag, pol & env)
- rev regulates the balance of transcription of the regulatory proteins (tat & rev) versus the structural proteins (gag, pol & env)
- nef:
- causes downregulation of the expression of CD4 on the host cell surface
- causes downregulation of the expression of CD4 on the host cell surface
- vpr, vpu & vif:
- the roles of these proteins are not well characterised
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