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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Langerhans cell histiocytosis includes a variety of clinical syndromes including, in decreasing severity:

  • Letterer-Siwe disease
  • Hand-Schuller-Christian disease
  • eosinophilic granuloma of bone

There is considerable overlap between these presentations, and more commonly Langerhans cell histiocytosis is used as a generic description for them all.

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