Conditions associated with paediatric malignancy

There are five categories of conditions which increased an individual's probability of malignant disease. Some of the conditions are listed below:

General:

• Beckwith Wiedemann syndrome
• hemihypertrophy
• multiple exostosis
• neurofibromatosis

DNA repair defects:

• ataxia telangiectasia
• Fanconi anaemia
• xeroderma pigmentosa

Immune deficiency disorders:

• common variable immune deficiency
• severe combined immune deficiency
• Wiskott Aldrich syndrome

Chromosomal abnormalities:

• 11p13 deletion (Wilms' tumour)
• 13q14 deletion (retinoblastoma)
• trisomy 21 (Down syndrome)

Familial syndromes:

• familial adenomatous polyposis
• familial Hodgkins disease

Reference

1. Schmidberger H et al. Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies. Cancers 2021, 13(11), 2607