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Platelets and inflammation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Platelets may be activated directly by inflammatory physical exposure of damaged subendothelium. This triggers the haemostatic cascades which protect the damaged surface and limit haemorrhage.

Alternatively, stimulation from on-going inflammation may come from platelet activating factor released from mast cells on degranulation, or antigen-antibody complexes which bind to specific receptors on the surface of platelets.

The mediators released by platelets can have many roles:

  • 5-HT, prostaglandins and lysosomal contents stimulate vascular contraction and increased vessel permeability
  • platelet derived growth factors important role in fibroplasia, angiogenesis and re-epithelialization

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