Complications

When the CD4 count falls below 50x10^6 per litre the typical

• atypical mycobacterial infections:
  • the most common micro-organisms are the mycobacterium avium complex
    
    
• systemic fungal infection:
  • Cryptococcus neoformans
  • Histoplasma capsulatum in the Americas
    
    
• candidiasis
  
  
• CMV disease:
  • retinitis
  • colitis
  • oesophagitis
  • encephalitis
  • radiculitis
    
    
• neoplastic disease:
  • Kaposi's sarcoma
  • high-grade B cell non-Hodgkin's lymphoma
    
    
• neurological complications:
  • AIDS dementia complex
  • progressive multifocal leucoencephalopathy
  • primary cerebral lymphoma
  • peripheral neuropathy or myopathy which may be complications of nuceloside analogue therapies